The synthesis and preliminary
pharmacological evaluation of 4-methyl fentanyl
by
Micovic IV, Ivanovic MD, Vuckovic SM,
Prostran MS, Dosen-Micovic L, Kiricojevic VD
Faculty of Chemistry,
University of Belgrade,
FR Yugoslavia.
Bioorg Med Chem Lett 2000 Sep 4; 10(17):2011-4

ABSTRACT

The synthesis of 4-methyl fentanyl, a prototype of a novel class of fentanyl analogues has been effected in 5 steps, starting from N-ethoxycarbonyl-4-piperidone (approximately 20% overall yield). In the key step, N-phenylation of secondary aliphatic amide intermediare was achieved by a novel reaction, using diphenyliodonium chloride for the phenyl group transfer. Preliminary pharmacological results indicate that 4-methyl fentanyl is a super potent narcotic analgesic, about four times more potent than fentanyl.

Pain
Morphine
Tramadol
Tolerance
Fentanyl for cats
Dihydroetorphine
Intravenous rush
Fentanyl analogs
Fentanyl: structure
Fentanyl: synthesis
Fentanyl and ketamine
Opioids and anaesthesia
Remifentanil and alfentanil
Fentanyl: subjective effects
From codeine to transdermal fentanyl

Refs
HOME
HedWeb
BLTC Research
Designer Drugs
Paradise-Engineering
The Hedonistic Imperative
When Is It Best To Take Crack Cocaine?