Abuse liability of buprenorphine -
a study among experienced drug users
by
Bedi NS, Ray R, Jain R, Dhar NK
Department of Psychiatry,
All India Institute of Medical Sciences,
New Delhi.
Indian J Physiol Pharmacol 1998 Jan; 42(1):95-100

ABSTRACT

Six male post-detoxified opiate dependent subjects were evaluated for abuse liability of buprenorphine (0.6 mg), morphine (16 mg), pentazocine (30 mg) and distilled water (placebo) intramuscular injection in a single blind cross-over random order. Subjective states, drug discrimination, drug linking, sedation and euphoria were assessed at pre-injection, 30 min and 4 hrs post-injection. Buprenorphine caused significant euphoria and was identified as heroin. On all parameters, buprenorphine resembled morphine rather than pentazocine and placebo. The data suggest that abuse liability of buprenorphine is similar to morphine i.e. moderate rather than low.

Pain
LAAM
Opioids
Arousal
Fentanyl
Tramadol
Tolerance
Nociceptin
Methadone
Remifentanil
Endomorphins
Norbuprenorphine
LAAM v methadone
Opioids and depression
Buprenorphine and naltrexone
Buprenorphine and the receptors
Buprenorphine as an antidepressant

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