Biological production of semisynthetic
opiates using genetically engineered bacteria
by
French CE, Hailes AM, Rathbone DA,
Long MT, Willey DL, Bruce NC.
Institute of Biotechnology,
University of Cambridge, U.K.
Biotechnology (N Y) 1995 Jul;13(7):674-6

ABSTRACT

Semisynthetic derivatives of morphine and related alkaloids are in widespread clinical use. Due to the complexity of these molecules, however, chemical transformations are difficult to achieve in high yields. We recently identified the powerful analgesic hydromorphone as an intermediate in the metabolism of morphine by Pseudomonas putida M10. Here we describe the construction of recombinant strains of Escherichia coli that express morphine dehydrogenase and morphinone reductase. These strains are capable of efficiently transforming the naturally occurring alkaloids morphine and codeine to hydromorphone and the antitussive hydrocodone, respectively. Our results demonstrate the potential for recombinant DNA technology to provide biological routes for the synthesis of known and novel semisynthetic opiate drugs.

Pain
Codeine
Fentanyl
Tolerance
Opium timeline
Hydromorphone
Opioid receptors
Endomorphins 1 and 2

Refs
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