Crack Cocaine
Cocaine is a powerful constrictor of blood vessels and a local anaesthetic. It is also a potent psychostimulant. Its effects include excitement, alertness, tachycardia, pupillary dilatation, raised body-temperature, hypertension, brochodilation, enhanced glucose availability, and increased motor activity - a part of the fight/flight syndrome. Taking cocaine also also gets you high. Its half-life in the plasma, however, is only 50 minutes; and the euphoria soon fades. Crack users desire more far sooner.The rewarding properties of cocaine derive mainly from its effects on the neurotransmitter dopamine. The dopamine system is involved in the control of mood, motivation, cognition, locomotion, sexuality and endocrine function. There are only some 30-40 thousand dopamine neurons in the brain, but both the axons and dentrites of the dopamine neurons are unusually well arborised - with as many as 100,000 synapses for each dopaminergic neuron. Their distinctive morphology reflects dopamine's role in the "encephalisation of emotion".
Cocaine induces elation primarily by blocking the dopamine transporter. The blockade increases the availability of free dopamine in the mesolimbic pleasure-centres of the brain. Degree of transporter occupancy is correlated with the intensity of euphoria. Higher doses and faster routes of administration create vivid memories and intense cravings.
Unlike most clinically-approved mood-brighteners, cocaine is a pro-sexual drug. Taken before sex, it can induce prolonged and intense orgasm. Cocaine-induced lovemaking, however, is not especially warm or empathetic.
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