Modafinil treatment of opioid-induced sedation
by
Webster L, Andrews M, Stoddard G.
Alpine Pain and Addiction Medicine,
Salt Lake City, Utah;
Department of Internal Medicine,
University of Utah School of Medicine,
Salt Lake City, Utah..
Pain Med. 2003 Jun;4(2):135-40

ABSTRACT

STUDY OBJECTIVE: The purpose of this study was to assess the efficacy of modafinil in combating opioid-induced sedation. DESIGN: A 1-year retrospective chart review of all patients receiving modafinil, a wake-promoting agent, to treat opioid-induced sedation. Opioid-induced sedation was measured using Epworth Sleepiness Scale (ESS). SETTING: Outpatient, private practice. PATIENTS: Eleven adult patients, six female and five male, being treated with opioids for chronic, nonmalignant pain. RESULTS: A significant decrease was observed between pretreatment and posttreatment ESS measurements during modafinil treatment. CONCLUSION: The results suggest an improvement in opioid-induced sedation in patients treated for nonmalignant pain.

Mice
Rats
Dogs
Cats
Monkeys
Guinea-pigs
Narcolepsy
Modafinil and the aviator
Modafinil as an antidepressant
Modafinil versus amphetamine
Modafinil versus methylphenidate
Modafinil, amphetamine and sleep

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