The rewarding properties of cocaine derive mainly from its effects on the neurotransmitter dopamine. The dopamine system is involved in the control of mood, motivation, cognition, locomotion, sexuality and endocrine function. Cocaine induces elation primarily by blocking the dopamine transporter. The blockade increases the availability of free dopamine in the mesolimbic pleasure-centres of the brain. Degree of transporter occupancy is correlated with the intensity of euphoria. Higher doses and faster routes of administration create vivid memories and intense cravings.
Unlike most clinically-approved mood-brighteners, cocaine is a pro-sexual drug. Taken before sex, it can induce prolonged and intense orgasm. Cocaine-induced lovemaking, however, is not especially warm or empathetic.
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