Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction
by
Diamond LE, Earle DC, Rosen RC, Willett MS, Molinoff PB.
1Palatin Technologies, Inc.,
Cranbury, New Jersey, USA.
Int J Impot Res. 2004 Jan;16(1):51-9

ABSTRACT

PT-141, a cyclic heptapeptide melanocortin analog, was evaluated following intranasal administration in healthy male subjects and in Viagra-responsive erectile dysfunction (ED) patients. Erectile response was assessed by RigiScan in healthy subjects without visual sexual stimulation (VSS) and in Viagra((R))-responsive ED patients with VSS. In healthy subjects, mean C(max) and AUC((0-t)) increased in a dose-dependent manner. Median T(max) was 0.50 h and mean t(1/2) ranged from 1.85 to 2.09 h. In both studies, an erectile response induced by PT-141 administration was statistically significant, compared to placebo, at doses greater than 7 mg, with the onset of the first erection occurring in approximately 30 min. PT-141 was safely administered and well tolerated in both studies. A maximum-tolerated dose was not identified. Flushing and nausea were the most common adverse events reported in both studies and no clinically significant changes in vital signs, laboratory tests, ECGs, or physical exams were observed. Based upon its erectogenic potential and tolerability profile, PT-141 is a promising candidate for further evaluation as a treatment for male ED

PT-141
Vardenafil
Yohimbine
Passion pills
Apomorphine
Testosterone
Phentolamine
Coolidge effect
Long-term Viagra
PT141 : "Bigger Than Viagra"
Semen as an antidepressant?
The 21st Century Aphrodisiac?
Yohimbine and sexual performance
The pharmacology of penile erection
Viagra leaves fake aphrodisiacs flagging
Viagra v Levitra as recreational sex-drugs
Sexual health : drug combination therapies
Sex drugs : the melanocortin agonist PT-141
Safety, pharmacokinetics, pharmacodynamics
Lust drug and slimming pill : PT-141 ("Passion")
PT-141/bremelanotide sexually arouses women

HOME
HedWeb
Future Opioids
BLTC Research
Superhappiness?
Paradise-Engineering
The Abolitionist Project
The Hedonistic Imperative
MDMA: Utopian Pharmacology
When Is It Best To Take Crack Cocaine?

The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family