Selective facilitation of sexual solicitation in the
female rat by a melanocortin receptor agonist
by
Pfaus JG, Shadiack A, Van Soest T, Tse M, Molinoff P.
Center for Studies in Behavioral Neurobiology,
Department of Psychology,
Concordia University, Montreal, QC,
Canada H4B 1R6;
Palatin Technologies, Cranbury, NJ 08512.
Proc Natl Acad Sci U S A. 2004 Jun 28

ABSTRACT

Disorders of sexual desire affect an estimated 30% of women in North America and Europe, with etiologies based on interpersonal, personal, and physiological factors. There are currently no pharmacological agents approved for use in the treatment of female sexual dysfunction. This is due, in part, to a focus on the effects of experimental drugs on reflexive components of sexual behavior, such as lordosis, in animal models. Here we report that PT-141, a peptide analogue of alpha-melanocyte-stimulating hormone that binds to central melanocortin receptors, selectively stimulates solicitational behaviors in the female rat. This occurs without affecting lordosis, pacing, or other sexual behaviors. PT-141 did not cause generalized motor activation, nor did it affect the perception of sexual reward. A selective pharmacological effect on appetitive sexual behavior in female rats has not been reported previously, and indicates that central melanocortin systems are important in the regulation of female sexual desire. Accordingly, PT-141 may be the first identified pharmacological agent with the capability to treat female sexual desire disorders.

PT-141
Vardenafil
Yohimbine
Passion pills
Apomorphine
Testosterone
Phentolamine
Coolidge effect
Long-term Viagra
Viagra: mechanisms
Viagra: clinical efficacy
PT141 : "Bigger Than Viagra"
Semen as an antidepressant?
Yohimbine and sexual performance
The pharmacology of penile erection
Viagra leaves fake aphrodisiacs flagging
Viagra v Levitra as recreational sex-drugs
Sexual health : drug combination therapies
Sex drugs : the melanocortin agonist PT-141
Safety, pharmacokinetics, pharmacodynamics
Lust drug and slimming pill : PT-141 ("Passion")
Preclinical CNS effects of PT-141/bremelanotide on female sexual function

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