Melanocortin peptide therapeutics: Historical milestones, clinical studies and commercialization
by
Hadley ME, Dorr RT.
Departments of Cellular Biology and Anatomy (MEH) and Medicine (RTD),
College of Medicine,
University of Arizona,
Tucson, AZ 85721, USA.
Peptides. 2006 Apr;27(4):921-30.

ABSTRACT

The melanocortins (MCs) are a family of multifunctional peptidergic hormones. Several superpotent, prolonged acting, enzymatically resistant, MC analogs have been designed and synthesized to help clarify the nature and role of MCs and their receptors (MCRs) in physiological functions. Two of these analogs, a linear peptide, melanotan I, and a cyclic truncated peptide, melanotan II (MTI and MTII, respectively) have been patented and tested clinically for studies on tanning of the skin (MTI) and for diagnosis and treatment of male erectile dysfunction (MTII). A new MTII analog, PT-141 (Palatin Technologies) has initial phase I/II trials and is scheduled to enter pivotal stage III clinical trials leading to commercialization. MTI may provide a therapeutic tan with the potential to lower the risk of skin cancer. PT-141 may improve sexual functionality in both males and females.

PT-141
When Viagra fails...
PT-141 arouses women
Novel CNS-active aphrodisiacs
Safety, pharmacokinetics, pharmacodynamics
PT-141 sex drug taken as a nasal spray: safety
Lust drug and slimming pill : PT-141 ("Passion")
PT-141/bremelanotide sexually arouses women
PT-141 (bremelanotide, 'Passion'): the first aphrodisiac
Overview of preclinical CNS effects on female sexual function

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